This thesis report focused on the structural redesign of Center for Drug Evaluation and Research Office Building 2 (CDER2).  Additional loading scenarios were explored as the progressive collapse effects of a blasted column were explored.  Critical columns to be removed, plus the necessary load combinations, for an alternative path, static analysis were determined through referencing various design guides and standards.  Two designs were performed, both of which considered identical loading and column removal cases. Additionally, the atrium curtain wall and office window were both designed to resist blast loading.  The conductance and heat transfer properties of these new units were then analyzed for summer and winter design conditions.